Data-Driven Insights for Drug Kinetics & Dynamics in Therapeutic Strategies
summary
Shows concrete results: fits nonlinear mixed-effects population modeling to clinical and real‑world PK/PD data, quantifies interindividual, interoccasion and residual variability, and produces covariate equations. Uses roughly 130 patients with 1–2 concentration samples in an epilepsy dataset to show body weight, co‑medication and total daily dose drive exposure and to compute individualized dose adjustments. Builds PK models, runs simulations of alternative regimens for pregnant, HIV‑positive women in malaria prophylaxis, and reports which standard regimens fail and which simulated regimens restore protective concentrations.
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chapters (10)
- 0:00Introduction
- 3:11Drug journey in body
- 6:44Clinical trials data
- 9:14Drug response variability
- 12:06Limitations of traditional models
- 14:14Population modeling
- 17:02Pharmacometrics applications
- 21:17Epilepsy treatment case
- 25:50Malaria prevention study
- 29:05Precision medicine future
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