Implementation of a clinical trial recruitment support system
summary
A FHIR R4-based CTRS imports EHR data (labs, echo) as FHIR Observations mapped to SNOMED CT/LOINC/ATC, records trials with ResearchStudy and models OR logic by creating multiple Group resources (ResearchStudy+multiple Group workaround). A web UI translates protocol trees for study staff and produces a real-time screening list; the system flags missing labs and allows manual statuses. In evaluation it identifies 52 of 55 enrolled patients, works despite data-entry and fluctuating-lab problems that required broader ranges and raised consent/legal questions; next move is EvidenceVariable in R5.
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chapters (7)
- 0:00Introduction and motivation
- 3:55Clinical trial recruitment challenges
- 7:50FIRE-based eligibility criteria implementation
- 10:18User interface and screening tool
- 12:47Project results and limitations
- 14:34Future of FIRE and interoperability
- 16:04Q&A session
