Profiling of Antibody Repertoires and Immunoglobulin Loci Enables Large-Scale Analysis of...

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" summary

Uses Rep-seq and WGS data to link specific germline variation and recombination mechanics to real repertoire outcomes. QTLs show a ~5 kb locus controlling multiple V genes; 55 V, 27 D, 7 J genes are surveyed. Cryptic RSS nonamers explain ~95% of observed VDDJ (tandem D) events. A conserved 5I‑D‑F‑N‑G motif appears in ~4% of unexposed humans and yields cross‑variant neutralization. A tool called IGDetective finds >1,000 V genes across ~20 mammalian genomes and highlights a 4‑cysteine V family enriched in bats.

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" chapters (5)

1. 0:00Start
2. 0:53Studying immune responses
3. 5:01Antibody repertoires and responses
4. 19:54Discovery of novel immunoglobulin genes
5. 21:47New family of bat immunoglobulin V genes

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