Multiple Sequence Alignment for Predicting Antigen-Antibody Interactions
summary
MAFFT gains a codon-based alignment option and a multi-step workflow that preserves novel insertions so millions of SARS-CoV-2 genomes can be aligned efficiently; four MSA products are now distributed. AlphaFold-Multimer is evaluated and fails often for antigen–antibody complexes (about half success on RBD subset, only 3 of 25 on a broader set). A prototype InterClone clustering groups antibodies by CDRs; CDR identity partially separates binders but needs more paired epitope data to train models.
AI-written summary · about