Denny Ausiello interviewed by Colin Hill
summary
CATCH builds continuous, minimally intrusive phenotype measurement to match genomic data: continuous glucose monitoring in 500 type 2 diabetics over three weeks reveals two distinct glycemic clusters that may track cardiovascular risk; a wearable Anna patch with ~100 nanotubes samples ~10,000 immune cells per day to detect cytokine rises 10–12 days before lupus flares; passive cellphone signals via Ginger.io phone analytics predict illness about ten days ahead. Current problems cited: <30% drug adherence and ~35% phase‑3 trial failures due to heterogeneous cohorts.
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chapters (13)
- 0:00Introduction
- 0:26How do we assess the human condition
- 5:30Center for Assessment Technology Continuous Health
- 11:09Behavioral Health
- 11:30Environmental Health
- 12:06Pathway Inspired Measurements
- 13:41The Phenotype
- 14:39Continuous Glucose Measurement
- 16:23Continuous Immune Measurement
- 18:48Human Target Validation
- 19:18Diabetes
- 20:55Ginger IO
- 22:00Lupus
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