Interaction-based Evolution: How Natural Selection and Non-accidental Mutation Work Together

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" summary

Argues mutation is a biologically directed, computational process that combines information from multiple loci rather than pure accident, supported by molecular and comparative data: poly de novo gene (785 nt) counters simple chance origin, transposable elements helped form >1,500 genes in placental endometrium, meiotic hotspots arise from combinatorial binding, and CpG changes account for 25% of point mutations; recurring malaria‑resistance alleles (e.g. HbS arose ≥4 times) and repeated alpha thalassemia deletions fit nonrandom mechanisms.

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" chapters (14)

1. 0:00Start
2. 2:04Poldi: a de novo gene
3. 3:13Transposable elements
4. 10:05Problem 2
5. 10:57Shifting Balance Theory
6. 12:33Problem 3
7. 17:21What is accident? A disruption
8. 21:16The core of my theory
9. 22:50New point of view: Interaction-based evolution
10. 31:03Rearrangement mutation is nonrandom
11. 32:07Point mutation is nonrandom
12. 36:48Multiple fundamental differences between germline and soma
13. 37:54Neutrality, genetic load, and
14. 38:44The paradox of variation