Birth and Death of Fragile Chromosomal Regions in Mammalian Evolution

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Computational proof shows the random breakage model fails: breakpoint graphs and a two-break distance algorithm give a minimum of 245 two-break events between human and mouse, far above the ~140 expected under random cuts. The work builds fast polynomial algorithms to compute distances from multichromosomal genomes, compares hundreds of genomes to map reuse of breakpoints, and proposes fragile region turnover as the mechanism. It ends by proposing sequencing ~200 primate genomes to predict future rearrangement hotspots.

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" chapters (18)

1. 0:00Start
2. 8:24Theory #1: The Master Alu Theory
3. 14:17Genome Rearrangements
4. 15:12Transforming Mice into Men
5. 15:51Evolutionary Earthquakes
6. 19:41Does RBM Have Predictive Power?
7. 20:33Lengths of Real Human-Mouse Synteny Blocks
8. 21:13Reversals
9. 22:40Philadelphia Chromosome
10. 24:13Rearrangements in Multichromosomal Genomes
11. 25:06From Sorting Pancakes to Sorting Genomes
12. 27:25From Linear to Circular Chromosomes
13. 36:242-Break Distance Theorem
14. 37:122-Break Distance between Human and Mouse Genomes
15. 38:29Are There Fragile Regions in the Human Genome?
16. 40:29A Contradiction!
17. 41:52Computational Tests vs. Biological Models
18. 50:04Reconstructing Rearrangement History of All Mammals