Exploring the Source Code of the Pfizer/BioNTech Vaccine
summary
A breakdown of the Pfizer/BioNTech mRNA vaccine sequence into six functional parts: a 5' cap that mimics human mRNA, a 5' UTR from alpha-globin to boost expression, a codon-optimized coding region with pseudouridine substitutions and two proline mutations to stabilize the spike protein, a 3' UTR of unclear function, and a long poly(A) tail. Explains that the sequence is chemically synthesized by RNA synthesizers and, once translated in cells, produces a stabilized spike protein that triggers immune recognition.
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chapters (8)
- 0:00Conference presentation
- 0:55Presentation of SARS-CoV-2
- 3:06The source code of the vaccine
- 5:24The untranslated region
- 6:16The signal peptide
- 7:14The shipping label
- 8:44The Spike protein
- 10:58Conclusion
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