Slush Science Pitching Finals 2017: Johan Seijsing
summary
Antibiotic resistance kills ~700,000 people this year and could reach 10 million by 2050 with a $100 trillion GDP loss, so the project develops enzymes derived from phages that lyse bacterial cell walls and make bacteria “pop.” Engineering focuses on stability for hospital storage, altered specificity to spare beneficial species, and higher activity. A library of millions of variants is assembled from modular parts and a high-throughput sorting method is ready to start screening. Proteins are produced recombinant in bacteria and delivered by injection like antibodies.
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