Towards the Deployment of Secure Computation Tools in Genomics: A Sociotechnical
summary
A secure genotype imputation pipeline called SMac secure genotype imputation runs inside Intel SGX with side-channel mitigations, reproducing state‑of‑the‑art accuracy and near‑practical speed while adding algorithmic measures to reduce known SGX side channels. Deployment barrier is not performance but a misaligned threat model: current MPC/TEE assumptions disrupt genomic norms. A trust‑first framework is proposed that treats adversaries as external, makes information flows explicit, and reframes secure computation as system‑level leakage control; work with practitioners to retool SMac is ongoing.
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chapters (8)
- 0:00Introduction
- 0:48What is Genomics
- 2:12Work in Progress
- 4:24Contextual Integrity Framework
- 6:15Disruption of genomic context
- 9:01What we want
- 9:25Trust
- 12:26Wrapup
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