Locknote: Reasons to be Cheerful: 0, 1, 2
summary
AI models run locally: Qwen 3.6 and Gemma 4 execute on an M3 Max laptop with 36 GB RAM using 4‑bit quantization (NVFP4), letting coding agents produce usable code when paired with review. Medicine sees concrete wins: personalized CRISPR base editing cures a baby’s CPS1 deficiency, AlphaFold wins a chemistry Nobel, and lenacapavir gives twice‑yearly HIV prevention. Fusion achieves ~4× energy gain in laser shots (2 MJ in, 8 MJ out, eight experiments). Security flags: 380,000 vibe‑coded apps found, 5,000 leaking data.
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chapters (18)
- 0:00Welcome
- 2:58AI in medicine
- 9:00Sustainable AI
- 12:12AI for developers
- 13:40Vibe coding risks
- 16:31Flying cars today
- 19:01Robotics progress
- 21:32Care robots
- 22:55CRISPR therapy
- 25:273D organs food
- 26:08Climate solutions
- 27:52Fusion energy
- 29:20Quantum computing
- 33:13Weather forecasting
- 34:38Microsoft qubits
- 36:22Audience stories
- 44:47Mental health
- 52:35Closing reflections
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