DNA data storage: A generative tool for Motif-based DNA storage
summary
A generative algorithm builds motif alphabets base-by-base using Markov chains and log-score penalties for homopolymer, hairpins, GC content and to avoid key sequences, producing reusable short DNA motifs for Gibson-style assembly. The motif generation tool outputs N motifs of given payload length and constraints, and returns a valid motif set in under <3 seconds for real-world IDT-like constraints, while DNA Fountain and other published encoders fail to find any valid set within a 5 minute threshold.
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