Update on Genetic Graph Using Massively Extended Neo4j
summary
A graph database called Variance of Inferred Conserved Effects (VOICE) models genes, variants, eQTLs and epigenetic peaks and integrates 29 billion peaks and connections into Neo4j using Neo4j Enterprise bulk import. Pipelines run with Nextflow + Kubernetes to produce terabyte-scale bulk files; counts show about 3.39 billion overlaps and roughly 800 million variant nodes. A Spring Boot + Angular front end and Jupyter/Python API produce CSV exports for analyses; a paper using the graph maps alcohol use disorder loci between mouse and human.
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chapters (10)
- 0:00Introduction and talk overview
- 3:26About The Jackson Laboratory
- 6:57Evolution of the genetic graph project
- 9:48Data sources and integration scale
- 10:53Graph schema and demo overview
- 16:36Querying the graph for research
- 16:56Nextflow for data ingestion
- 19:27Building a user interface
- 21:35Live demo of the web interface
- 24:31Future plans and conclusion
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