Tools for Understanding the Geography of Adaptation
summary
Models connect mutation arrival and spread to concrete spatial scales using Poisson cones for space time of successful mutations and subcritical branching families for migrant lineages. Calculations show the characteristic patch size depends weakly on dispersal and selection (one third power), producing numbers like ~1,000 km for sickle cell and ~350 km for G6PD, and a sharp transition where patches separated by tens to hundreds of kilometres adapt independently rather than by gene flow, with a typical 56 kb shared haplotype when migration wins.
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chapters (8)
- 0:00Introduction
- 1:02Blood Disorders
- 1:48G6PD
- 8:20Heterogeneous Landscape
- 11:54Notation
- 25:04Variance
- 30:57Migration
- 42:06Questions
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