~/talk

Genetic Diversity in the Interference Selection Limit

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Claims that genetic diversity under pervasive purifying selection is set primarily by the population variance in fitness rather than by individual s or Ud; uses structured coalescent approximations, extensive forward simulations and a coarse‑graining mapping that replaces many weakly selected sites with an equivalent strong‑selection model. Predicts mean pairwise diversity and distorted site‑frequency spectra across parameters, matches simulations except for small intermediate deviations, and extends to recombining genomes by defining a self‑consistent linkage block scale.

AI-written summary · about

  1. 0:00Intro
  2. 3:18Existing methods
  3. 8:04Framework
  4. 10:21Model
  5. 16:56Delay Time
  6. 20:43Simulations
  7. 22:04Results
  8. 23:16Standard Deviation and Fitness
  9. 25:56Interference Selection Limit
  10. 31:24Neutral Limit
  11. 35:45Recombination
  12. 37:45Distribution of Fitness Effects
  13. 38:23Discussion
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