Mutation Accumulation and Empirical Calibration
summary
A mutation‑accumulation model calibrated to hunter‑gatherer life tables and exome sequencing argues that the relevant class is mildly deleterious adult‑mortality alleles: sequencing suggests ~300 such sites per person, population genetic bookkeeping plus an epistasis correction (~50% effect) gives flows of about one MA mutation every five generations, typical selective cost s ≈ 10^-3, and average allele ages on the order of a thousand–two thousand generations so recent explosive growth mainly inflates nearly neutral variants.
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chapters (12)
- 0:00Introduction
- 5:46Preface
- 6:55Background
- 15:24Flows
- 23:08Stocks
- 31:08Summary
- 32:05Calculation
- 35:04The Frontispiece
- 36:36Population Science
- 37:10Population Structure
- 39:55Dominance Effects
- 40:54Empirical Calibration
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