Long-Range Propagation of Genetic Effects in Molecular Networks

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" summary

Cross of BY and RM yeast strains, matched RNA, protein (SWATH/DIA) and the first phospho-QTL layer, uses regression to remove abundance effects and random forest mapping to find genetic associations. A one-dimensional PT score (PKA/TOR activity) summarizes signaling and explains a large fraction of transcriptome, proteome and phosphoproteome variation, outperforms single QTLs (three QTLs for heat-induced lag including IRA2) and predicts heat-stress lag and longevity, showing local, regional and long-range propagation of genetic effects.

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" chapters (17)

1. 0:00Intro
2. 3:29Molecular traits are correlated
3. 4:49Correct for level changes ... same with protein-RNA
4. 5:55Random Forest QTL Mapping
5. 6:53Transcript versus protein changes
6. 8:35Cellular traits best explained by phosphorylation
7. 9:33Molecular networks get perturbed
8. 12:16Long-range effects in molecular networks
9. 14:12Genetic and molecular determinants of heat-induced lag duration
10. 18:07PKA- and TOR-related network state in yeast
11. 20:12PT network state reflects molecular reconfiguration
12. 22:01Cellular fitness traits associated with the PT network state
13. 24:16Cellular functions associated with the PT network state
14. 26:25Classification of network effects
15. 27:26Regional versus long-range effects
16. 29:16Conclusion
17. 30:51Acknowledgements

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