Mapping Neural Connections and Their Development I

on YouTube ↗01h 02m

" summary

Argues that mapping actual wiring requires Brainbow multicolor labeling plus serial electron microscopy and massive computer-assisted image analysis, not cartoons. Gives concrete scales: retina catalogs move from ~39 to 80+ cell types, C. elegans has ~300 neurons but complex connectivity, and nanometer voxels make a human whole-brain raw EM dataset on the order of yottabytes. Brainbow and EM work and produce surprising complexity; whole-brain connectomics remains technically possible but currently intractable.

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" chapters (13)

1. 0:00Program overview
2. 3:38Introduction of the speaker
3. 5:05The science U formulation
4. 7:57Biological reductionism
5. 12:59Cajal's neuron doctrine
6. 17:20Behavioral causality
7. 20:14Axioms of neurobiology
8. 23:08Defining connectomics
9. 25:51Critique of simple models
10. 33:41Genetics vs. experience
11. 39:35Complexity of cell types
12. 45:45Data scale challenges
13. 56:41Concluding session