Programming Nanoscale Structure Using DNA-Based Information

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Describes programmable DNA motifs that produce working structures: 32 nm stripe spacing appears in AFM for DX 2D lattices; triangular DNA motifs self-assemble into macroscopic 200 µm crystals with rhombohedral lattices and cavities; diffraction reaches 3.0–3.4 Å (and ~4 Å from LCLS nanocrystals). Implements sequence-switchable PX/JX devices, an inchworm and a somersaulting walker, a one‑dimensional XOR algorithmic assembly, and a nanoscale assembly line with 5 nm and 10 nm nanoparticles confirmed by TEM.

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" chapters (34)

1. 0:00Introduction to DNA Nanotech
2. 0:31Bones and Building Blocks
3. 1:55DNA Structural Properties
4. 3:20Reciprocal Exchange Technique
5. 5:38Algorithm for Junction Design
6. 7:03Inspiration from Art and Lattices
7. 8:33Sticky-Ended Cohesion
8. 10:35Goals of DNA Nanotechnology
9. 11:34The Crystallization Problem
10. 12:37Nano-Electronics Application
11. 13:38Topological Control in Design
12. 14:53Polyhedral Catenae Construction
13. 15:59Creating 2D DNA Arrays
14. 17:24DX Molecules and Arrays
15. 19:193D DNA Crystals
16. 21:28Crystallographic Data and Structure
17. 23:27Controlling Crystal Cavities
18. 24:38Multi-Component Lattices
19. 25:50Functionalizing Crystals
20. 27:55DNA Nanomechanical Devices
21. 29:10PX and JX Molecules
22. 30:39Sequence-Dependent Switches
23. 31:42DNA Walking Devices
24. 32:24DNA-Based Computation
25. 35:05Algorithmic Assembly with Tiles
26. 37:48Error Reduction in Computation
27. 39:572D Algorithmic Assembly
28. 41:10DNA Origami and Patterns
29. 42:42Programmable Capture Protocol
30. 43:36Solving Graph Theory Problems
31. 45:27Nanoscale Assembly Line
32. 46:25Implementing the Assembly Line
33. 50:21Summary and Future Outlook
34. 52:13Question and Answer Session