Shweta Bhandare at StaffPlus London 2023
summary
Recursion runs CRISPR-Cas9 mediated knockout across the whole human genome in disease cell models, robots image cells, and deep learning embeddings convert images into features that map gene relationships (red similar blue opposite). The team scales from one cell-type map to an atlas by tagging experiments in the database, enforcing QC by 5 PM, and triggering a cron job + Slack integration that builds weekly map versions automatically so building multiple maps becomes trivial.
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chapters (8)
- 0:00Introduction
- 0:45Recursion’s mission and gene mapping
- 3:18Biology mapping challenges 2021
- 5:25Kent Beck’s scaling directive
- 7:12Event-driven system and QC SLA
- 8:35Automating map building
- 9:38Scaling map atlas
- 9:59System design principles
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