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A Flexible Framework for Hypothesis Testing in High-Dimensions

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Framework projects the high dimensional null onto a chosen K‑dimensional subspace then constructs a de‑biased estimator of U^T theta via a rotated debiasing step whose columns G are chosen by a quadratic program balancing bias and variance. Calibration uses sample splitting to pick U from a LASSO pilot and then tests by an L∞ projection onto Ω. Theory controls Type I error under sub‑Gaussian rows when S log p / sqrt n → 0 and shows convex Ω reduces to K = 1 with orthogonal projection, with project onto subspace U, de‑bias in rotated basis, data splitting to choose U.

AI-written summary · about

  1. 0:00Intro
  2. 0:28Statistical model
  3. 1:28Linear Models and Lasso Estimator
  4. 2:22Statistical Inference on model parameters
  5. 3:22Testing individual parameters
  6. 5:49Example 2 (Inference on Quadratic Forms)
  7. 7:02Testing minimum signal strength)
  8. 7:45Testing over Convex Cones)
  9. 8:37Testing arbitrary functionals of 8)
  10. 9:07Outline
  11. 10:55Debiasing (in rotated basis)
  12. 12:50How should we choose G?
  13. 17:25Step 3: Los projection and test statistic
  14. 18:46Summary
  15. 19:55Controlling false positive rate
  16. 21:20How should we choose basis U?
  17. 25:02Data splitting
  18. 29:32Examples
  19. 30:18Experiment 1
  20. 32:21Experiment 3: Inference on predictions Confidence intervals for ET
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