A Few Observations on the Marvelous Resilience of Bone & Resilience Engineering
summary
Claim: bone is the archetype of resilience because it is continuously remodeled on a roughly ten‑year timescale, directed by mechanical strain, and repurposes minerals for systemic needs. Evidence: callus formation, intramedullary nailing and external fixation show mechanical stabilization guides healing; signaling via PTHrP and drug modulation (abaloparatide) can shift remodeling and yields a reported 91 percent risk reduction for vertebral fractures; caution: direct resilience modulation creates new hazards.
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chapters (15)
- 0:00Start
- 2:34Conclusion
- 2:46Bone Is Continuously Remodeled
- 3:25Dynamic Balance between Creation and Destruction
- 6:14Bone Has both a Complex Macro and Micro Architecture
- 9:09The Remodeling of Bone
- 13:11The Resilience of Bone and the Methods of Repair
- 17:09External Fixation
- 17:20Internal Fixation
- 17:41Intramedullary Nail
- 18:50Orthopedic Surgeons Do Not Heal Bone
- 20:30Broken Bone of the Arm
- 23:09Bone Is Not Perfect
- 24:11Osteoporosis
- 25:16Consequences of Osteoporosis
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