Hindering Evolution in Prostate Cancer
summary
A hybrid agent-based + PDE model recreates trabecular bone homeostasis and prostate cancer bone metastases on roughly a 500×200 grid with ~20 μm cell sites, using literature and collaborator experiments for flowchart rules and chemical fields. The simulation reproduces mouse pathology and cell-type oscillations, shows that small stochastic founder populations often fail or succeed unpredictably, finds bisphosphonates largely ineffective while anti-RANKL works only with unrealistically complete delivery, and identifies TGF-β inhibition as a promising target under tumor heterogeneity constraints.
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