How Genome 3D Organization Regulates Alternative Splicing?
summary
Study demonstrates that genome 3D position links GC architecture to splicing mode: low-GC differential versus level GC architectures map to the nuclear periphery and center respectively, and peripheral genes (long low-GC introns, higher-GC exons) undergo exon definition and exon skipping while central genes (short introns, high GC overall) favor intron definition and intron retention. Evidence uses Hi-C, lamin ChIP-seq, RNA FISH, 86 iCLIP datasets, ANAT network analysis, splice‑site cancer mutations, mini‑gene insertions and lamin knockout; a 50-nt GC swap shifts nuclear position and splicing.
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